Cities Skylines with high-res MODs causes Crucial DDR4 2400MHz 8GB memory errors, do I need to tweak timings manually?

I finally got a clean bill of health after 4 rounds of MemTest86 with zero errors. Before that, it was a nightmare. I used the GamePP BIOS Load-Line Voltage Adjust Wizard to tweak my Crucial DDR4 2400MHz timings from 17-17-17-39 down to 16-16-16-36 and bumped the voltage from 1.2V to 1.25V. AIDA64 showed latency dropping from 88ns to 79ns. The initial experience was awful; once my city hit 100k population with high-res MODs, buildings just turned into grey blocks because the memory controller was choking on vertex data. I tried increasing the page file, but that just made loading take forever without fixing the textures.